This presentation will explore the interplay between nitric oxide (NO) bioavailability, vagus nerve signaling in neuroplasticity as a pillar of cognitive resilience. Dr. Habib will discuss the latest research on dietary and supplemental nitrate sources that enhance NO production, improving cerebral blood flow, reducing neuroinflammation, and supporting memory consolidation. Attendees will learn how vagus nerve afferents relay gut-derived NO and microbial metabolites to the nucleus tractus solitarius (NTS), triggering acetylcholine release in the cerebrum.
Activation of this vagal pathway promotes microglial M2 polarization-a state critical for synaptic pruning, neurotrophic factor release, and lifelong neuroplasticity. Clinical insights include vagus nerve stimulation (VNS) protocols that slow hypertension progression and mitigate age-related cognitive decline by preserving autonomic balance and suppressing pro-inflammatory cytokines. Practical applications highlight nitrate-rich diets and VNS as tools to optimize the “microbiota-mouth-brain axis” for cognitive health.
This session bridges molecular mechanisms with translational strategies, equipping attendees to leverage NO-Vagus pathways for cognitive resilience across the lifespan.
Learning Objectives
- Analyze the role of dietary nitrates in enhancing NO bioavailability and their impact on cerebral blood flow, inflammation, and memory.
- Explain how vagus nerve afferent signaling integrates gut-derived NO with NTS activation to modulate acetylcholine release and microglial M2 states.
- Evaluate evidence linking vagus nerve signaling to improved autonomic tone, neuroinflammation reduction, and survival in hypertensive models.
- Design interventions combining nitrate supplementation, microbiota modulation, and non-invasive VNS to sustain neuroplasticity in aging populations.
Sponsor – Berkley Life
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