Precision Chiropractic for ‘Brain Fog’ Recovery in Long-COVID

Objectives:  

1. Viral Hijack of Neuropilin 1 (NRP1) Receptor in Brainstem: Neuropilin 1 (NRP1) located in the brainstem is the prominent receptor that SARS-CoV-2 hijacks for its host cell binding, invasion & initiation of viral infection cycle. The brainstem is a bundle of nerve tissue at the base of the brain that connects cerebrum and cerebellum to the spinal cord. Transmission of nerve signals from brain to other parts of the body is achieved through the brainstem. Brainstem also regulates several vital physiological functions such as heart rate, breathing, and blood pressure.

2. Brain Fog – an Adverse Interplay between Brainstem, Cervical Vertebra, and HMR/D: Vertebra C1, the Atlas, is first bone in the cervical (neck) region, closest to the brainstem. The functional health of the brainstem depends on optimum flow of blood and cerebrospinal fluid. Any misalignment of the atlas (C1) due to viral-induced HMR/D could dysregulate flow/function of these vital fluids and trigger chronic neuro-cognitive challenges, especially ‘brain fog’, a severe debilitating condition widely prevalent among long-COVID patients.

3. Upper Cervical Adjustment – an Effective Chiropractic Protocol to alleviate Brain Fog: Often an overlooked cause of impaired brain function due to brain fog is the upper cervical misalignment. The upper cervical adjustment has been a historical protocol in Chiropractic care for over a century to relieve brain fog symptoms. For decades, upper cervical chiropractors have been trained to detect and correct misalignments and reset brainstem for normal activity. Such holistic multi-facet chiropractic approach could also eliminate back pain, restore energy levels, improve anti-inflammatory fluid flow, reduce stress, and normalize bodily functions.

4. Precision Chiropractic–The New Paradigm Shift: Vertebral (Cervical) Adjustment combined with Metabolic Reset of viral-induced HMR/D could serve as an effective intervention protocol for Chiropractic Care to manage Sub-C

 

Description:   Several SARS-CoV-2 infected individuals display sensory impairments including loss of taste (ageusia), loss of smell (anosmia), and loss of pain sensation, as early clinical manifestations (instead of respiratory symptoms) during the disease onset. Several studies established that ‘Neuro-COVID’ is a distinct viral pathobiology compared to the regular onset of COVID with pulmonary/respiratory involvement. Global clinical data firmly established that SARS-CoV-2 infection targets brainstem, induces hyper-inflammation, leading to severe debilitating neuro-cognitive impairments that may last for months (even years) in COVID-19 survivors (those RT-PCR negative for the virus). Several Global Pandemic Surveillances reported that nearly 500 million individuals are suffering from long-COVID, a viral-induced human metabolic reprogramming/ dysregulation (HMR/D). Notably, about 30% of such affected population exhibit a plethora of neuro-cognitive impairments. ‘Brain Fog’ with characteristic poor memory, difficulty in thinking, mental clarity or concentration, stands out as a major persistent manifestation among long-COVID patients. Viral-induced HMR/D with altered glucose metabolism (the ‘Warburg Effect’), dysregulated tryptophan/kynurenine pathways (with mitochondrial dysfunction, mDys), augmented with hyper-inflammation and oxidative stress could trigger the clinical onset of brain fog. Other neuro-cognitive complications, such as chronic pain, migraine and myalgic encephalomyelitis-chronic fatigue syndrome (ME/CFS) are also widely reported in such patient population. As nerve cells or astrocytes do not readily regenerate after a severe viral-induced HMR/D, any brainstem dysfunction could ultimately lead to severe lingering health complications among long-COVID patients.
Sponsor:   HMRDO